Polynucleotides Treatments

Polynucleotides are one of the treatments selected by our experts as part of our Natural Response Treatments Collection – a carefully curated range of innovative treatments that naturally enhance and rejuvenate your appearance using your skin’s own mechanisms to deliver longer-lasting results without the need to restructure the face or add anything artificial.

Natural Response Treatments Collection

What are Polynucleotides?

Polynucleotides are a type of injectable bio-stimulator that consist of stretchy molecules crafted from fragments of DNA. Unlike traditional fillers that predominantly add volume, this injectable enhances skin quality by targeting free radicals, boosting hydration and promoting tissue regeneration. Experience the beauty of improved skin texture and vitality with this revolutionary treatment.

“Polynucleotides are a lovely new treatment modality that taps into the body’s own biological systems and helps to bio-regenerate the skin. It sends signals to the skin that result in the production of new collagen and elastin, helping the skin behave like it did in younger years. They give high-impact results in the softest and most natural way.”

Polynucleotide Treatment Benefits

Polynucleotides activate various beneficial transformations in skin behaviour, including:

• Improved skin texture and tone – Polynucleotides can help to improve uneven texture, dullness and roughness, leaving the skin looking smoother and more refined.
• Enhanced hydration – The treatment supports skin hydration from within, helping the skin look fresher, healthier and more luminous.
• Collagen and elastin support – Polynucleotides help to stimulate the skin’s natural repair processes, supporting collagen and elastin production for firmer, more resilient skin.
• Reduction in fine lines – By improving hydration, elasticity and skin quality, polynucleotides can help to soften the appearance of fine lines and crepey skin.
• Under-eye rejuvenation – Polynucleotides can be used in the delicate under-eye area to improve skin quality, soften crepiness and support a brighter, more refreshed appearance.
• Support for scarred or damaged skin – The regenerative properties of polynucleotides may help to support skin repair and improve the appearance of uneven or textured skin.
• Natural-looking, progressive results – Results develop gradually as the skin responds to treatment. The aim is to improve skin quality in a subtle, natural-looking way, rather than create visible volume or contour.

With its bio-remodelling properties, patients can enjoy the antioxidant and hydrating effect of the treatment with skin that looks and feels healthier.

Polynucleotides treatment areas

Polynucleotides can be used across several areas of the face and body where skin quality, hydration and regeneration are key concerns.

Polynucleotides for the face

Polynucleotides can help to improve overall skin texture, hydration, elasticity and radiance on the face. They may be suitable for patients concerned with dullness, enlarged pores, fine lines, uneven tone or early signs of ageing. This treatment can be used as part of a wider skin-quality plan, particularly for patients who want to improve the condition of the skin without adding volume. In some cases, your practitioner may recommend combining polynucleotides with treatments such as Profhilo, babyGLOW™ Skin Booster or Morpheus8 depending on your skin goals.

Polynucleotides under eyes

The under-eye area is delicate and can be one of the first places to show signs of fatigue and ageing. Polynucleotides may be recommended for patients concerned with dark circles, crepey skin, fine lines, tired-looking eyes or soft hollowing beneath the eyes. Unlike tear trough filler, which is designed to restore volume, polynucleotides focus on improving the quality and resilience of the under-eye skin. They may be suitable for patients who are not suitable for tear trough filler or who would benefit from a more regenerative approach. For patients researching under-eye rejuvenation more broadly, your practitioner may also discuss related tired eyes treatments or dark circles treatments.

Polynucleotides for the neck

The neck can become crepey, dry or lax as collagen and elastin levels decline. Polynucleotides may help to improve hydration, texture and firmness in this delicate area. They may be suitable for patients with mild neck crepiness, fine horizontal lines or early signs of skin laxity. For patients with more significant laxity, your practitioner may recommend combining polynucleotides with treatments such as Profhilo, Morpheus8 or non-surgical neck lift treatments.

Polynucleotides for hands

The hands can reveal signs of ageing through thinning skin, crepiness, dehydration and reduced skin quality. Polynucleotides may be used to support skin repair and improve the appearance of tired or ageing hands. This treatment can be particularly useful where the concern is skin quality rather than volume loss. If veins, tendons or hollowness are more prominent, your practitioner may recommend a dedicated hand rejuvenation treatment plan, which may include other injectable options depending on your concerns.

How do Polynucleotide injection treatments work?

Polynucleotide injectables work by stimulating collagen and elastin production in the skin’s cells. Polynucleotide injections trigger two key transformations in skin behaviour. Initially, they act as wound healing agents, prompting intensive skin repair, which reduces scar tissue, including stretch marks, and smoothing uneven or textured patches on the skin. Polynucleotides also possess anti-inflammatory properties that stimulate cell renewal, promoting cell renewal, collagen synthesis, elasticity, and hydration, ultimately reducing wrinkles.

Unlike traditional fillers, polynucleotide injectables gradually dissipate after activating the skin’s regeneration, rather than remaining in place indefinitely.

Why choose The Cosmetic Skin Clinic for Polynucleotides?

Polynucleotides are one of the most talked-about treatments in regenerative aesthetics, but successful results depend on careful patient assessment, product knowledge and precise injection technique.

At The Cosmetic Skin Clinic, our approach is focused on safe treatment planning, subtle outcomes and long-term skin quality. Your practitioner will assess your skin, treatment area and goals before recommending whether polynucleotides are the right option for you.

• Over 27 years of aesthetic expertise – The Cosmetic Skin Clinic has more than 27 years of experience in medical aesthetics, with a reputation for subtle, refined and natural-looking results.
• Experienced medical practitioners – Polynucleotides treatments are carried out by qualified aesthetic practitioners with advanced knowledge of injectable treatments, skin quality and regenerative aesthetics.
• A carefully selected regenerative treatment – We are proud to offer Plinest polynucleotide injections as part of our skin regeneration treatment range. Your practitioner will explain how this treatment works and whether it is suitable for your specific skin concerns.
• Part of our Natural Response Treatments Collection – Polynucleotides sit within our Natural Response Treatments Collection, reflecting our focus on treatments that work with the body’s own regenerative processes rather than changing the face with excessive volume.
• Trusted clinic standards – The Cosmetic Skin Clinic is CQC registered and associated with respected professional standards within aesthetic medicine, including BCAM membership.
• Patient satisfaction and trusted results – Patients choose The Cosmetic Skin Clinic for practitioner expertise, high standards of care and natural-looking outcomes, reflected in our 5-star Trustpilot rating and strong patient satisfaction.

Contact our clinics today to book a consultation or give us a call on 0330 828 4665.