Polynucleotides London & Buckinghamshire

Unlock your skin’s natural regeneration with the power of Polynucleotide treatments.

Experience flawless skin with our latest treatment that is here to stay – Polynucleotides Injectables.

It could be the perfect match for your skin if you want to reduce hollowness, minimise pores, diminish fine lines, improve elasticity and have a brighter complexion.

Polynucleotides, hailed as the ‘Gold Standard’ in skin regeneration, work wonders on a cellular level, delivering impressive collagen stimulation   for rejuvenated skin and tissue.

To book a Polynucleotide treatment consultation at our clinics in London and Buckinghamshire, please get in touch with our expert practitioner team.

Medically reviewed by the MDT Advisory Committee for The Cosmetic Skin Clinic, London and Bucks. Last reviewed on 16th February 2024.

polynucleotides London Buckinghamshire polynucleotide injection

What are Polynucleotides?

Polynucleotides are a type of injectable bio-stimulator that consist of stretchy molecules crafted from fragments of fish DNA, chosen for their close resemblance to human DNA (no fish are harmed in the process).

Unlike traditional fillers that simply add volume, this injectable enhances skin quality by targeting free radicals, boosting hydration and promoting tissue regeneration. Experience the beauty of improved skin texture and vitality with this revolutionary treatment.

“Polynucleotides are a lovely new treatment modality that taps into the body’s own biological systems and helps to bio-regenerate the skin. It sends signals to the skin that result in the production of new collagen and elastin, helping the skin behave like it did in younger years. They give high-impact results in the softest and most natural way.”, Dr Johanna Ward, MA(OXON) MBBS DRCOG MRCGP Dip Clinical Dermatology – Cosmetic Doctor

Polynucleotide Treatment Benefits

Polynucleotides (like Ameela) can indeed activate various beneficial transformations in skin behaviour, including:

  • Wound healing
  • Scar reduction
  • Improvement of skin texture and tone
  • Anti-inflammatory effects
  • Stimulation of collagen production
  • Enhanced elasticity and hydration
  • Reduction of wrinkles
  • Additionally, polynucleotides typically dissipate gradually after providing their regenerative instructions.
  • Polynucleotide under eyes results can be seen quickly

With its bio-remodelling properties, patients can enjoy the antioxidant and hydrating effect of the treatment with skin that looks and feels healthier.

Polynucleotides treatment areas

At The Cosmetic Skin Clinic, our favoured brand of Polynucleotides is Ameela (previously called Nucleadyn), which can be used on the:

  • Face
  • Neck
  • Hands
  • Under the eyes

How do Polynucleotide injection treatments work?

Polynucleotide injectable treatments work by triggering two key transformations in skin behaviour. Initially, they act as wound healing agents, prompting intensive skin repair, which reduces scar tissue, including stretch marks, and smooths uneven or textured patches on the skin. Additionally, polynucleotides possess anti-inflammatory properties that stimulate cell renewal, boost collagen production, improve elasticity and hydration, and diminish wrinkles.

Polynucleotide treatment near me

At The Cosmetic Skin Clinic, our team of experts utilises the latest advancements in aesthetic medicine to ensure safe and effective treatments for our clients. With years of experience and specialised training, our practitioners are skilled in administering Polynucleotide injectable treatments with precision and care. We prioritise patient satisfaction and strive to achieve natural-looking results tailored to individual needs.

Polynucleotides are available at our clinics in London and Buckinghamshire. To find out more about the polynucleotide treatment and other treatments that can be combined with it, please get in touch with our London or Buckinghamshire expert practitioners. Explore our other collagen booster treatments.


Polynucleotides, an injectable bio-stimulator, feature stretchy molecules derived from fish DNA fragments, selected for their similarity to human DNA (no harm to fish). Unlike standard fillers, this groundbreaking treatment elevates skin quality by combating free radicals, enhancing hydration, and stimulating tissue regeneration.

Polynucleotide injectables work by stimulating collagen and elastin production in the skin’s cells. These injectables, composed of stretchy molecules derived from fragments of fish DNA, closely resembling human DNA, initiate a cascade of effects. They prompt intensive skin repair akin to wound healing, reducing scar tissue, including stretch marks, and smoothing uneven patches. Additionally, they exhibit anti-inflammatory properties, promoting cell renewal, collagen synthesis, elasticity, and hydration, ultimately reducing wrinkles. Unlike traditional fillers, polynucleotide injectables gradually dissipate after activating the skin’s regeneration, rather than remaining in place indefinitely.

With Ameela, as our polynucleotide of choice at The Cosmetic Skin Clinic, we would recommend having three treatments a month apart from one another. For maintenance sessions, we would recommend a top-up every 9 months for best results. This is all dependent on the patient and the concern area/s and our practitioners will provide you with all the advice you need.

Quick results are noticeable in areas like the under-eyes, although the product continues to stimulate for up to 12 weeks, resulting in a gradual onset of effects. For the face and neck regions, improvements in skin quality and elasticity become apparent after a few weeks, showcasing the effectiveness of the treatment.

As with all injectables, there can be the common side effects of slight swelling and bruising. This will be mild and only temporary. At your consultation, our practitioners will talk you through any and all concerns and questions you may have.

Polynucleotides offer natural-looking results with minimal risk. They enhance skin texture, address skin discoloration, and subtly increase volume and tightness, particularly under the eyes. With collagen-boosting properties and enhanced hydration, they act as a potent injectable moisture treatment. Suitable for both preventative care in younger skin and rejuvenation in aging skin, polynucleotides serve as versatile solutions for skin health and vitality.

We proudly offer Ameela, formerly known as Nucleadyn. It’s a great polynucleotide based skin booster which gives results of in-depth skin rejuvenation. You can find out more about Ameela treatment here.

After your initial 2-3 treatments, we recommend a top up every 9 or so months for best maintenance results.

At The Cosmetic Skin Clinic, our experienced team provide safe and effective Polynucleotide injectable treatments starting from £450. With specialised training, our practitioners administer treatments with precision, prioritising patient satisfaction and natural-looking results tailored to individual needs.

Polynucleotides are not a filler. Polynucleotides differ from fillers in that they lack hyaluronic acid. Instead, they consist of biopolymers, which are stretchy molecules derived from fragments of fish DNA. Despite these distinctions, polynucleotides synergize effectively with HA fillers, providing both immediate and long-term enhancements.

While hyaluronic acid skin boosters such as Profhilo, Teoxane Redensity 1, Belotero Revive, and Sunekos Performa primarily provide hydration, polynucleotides go a step further by stimulating collagen and elastin production in cells. Moreover, unlike many skin boosters, polynucleotides are effective in areas like the eyes, lips and forehead where others may not reach.

Polynucleotides can be seamlessly integrated into popular skin booster treatments like Profhilo and Sunekos, as well as various other treatments we provide. Your practitioner will expertly advise you on the optimal time to introduce additional complementary treatments into your personalised plan.

Polynucleotides can also be combined with other high-tech treatments. Our Dr Johanna Ward favours a double eye treatment combining Thermage Eyes with Ameela. Dr Ward says:

“The brilliant thing about polynucleotides is that they can be combined with any type of energy treatment. This is particularly good for dark circles, soft hollowing under the eye and addressing the crepey tissue around the eye.”

Polynucleotides treatments consultations are available at The Cosmetic Skin Clinic in London or Buckinghamshire.

  • The London clinic is situated at 8 Devonshire Place, Marylebone, London W1G 6HP.
  • The Buckinghamshire clinic is located in Stoke Poges at 84 Rogers Lane, Slough SL2 4LF.

Polynucleotides London – The Cosmetic Skin Clinic is conveniently situated close to Oxford Circus and Baker Street tube stations In London. Additionally, trains are accessible from Paddington and Kings Cross St Pancras stations.

Our London clinic is conveniently accessible from various surrounding boroughs, including:

Battersea, Bayswater, Belgravia, Chelsea, Earls Court, Fitzrovia, Fulham, Knightsbridge, Marylebone, Mayfair, Notting Hill, Primrose Hill, Regents Park, Soho, South Kensington, St Johns Wood, Green Park, Hampstead, Highgate, Holland Park, Hyde Park, Islington, Kensington, Kings Road, Victoria, West Brompton, Westminster and West End.

The nearest tube stations to our London clinic.

Polynucleotides Buckinghamshire – The Cosmetic Skin Clinic in Stoke Poges, Bucks, is conveniently situated near Gerrards Cross-Chiltern Railway and Slough-First Great Western stations. The clinic is easily accessible from Wembley, Richmond, Kingston upon Thames, and the Surrey area via quick transport links with major roads such as the M25, M4, M40, and A40.

Directions to our Stoke Poges, Buckinghamshire clinic.

Book your polynucleotides consultation here or give our London or Buckinghamshire clinic a call on 0343 253 8240.

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Buckinghamshire: +44 203 319 3637

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